MELATONINE COMPLEX 295MCG [Specialities]
Melatonin complex is a synergistic compound nutritional supplement that supports sleep quality.
MELATONINE COMPLEX 295MCG
Long-term body and mind overload leads to chronic stress which not only has adverse effects on nutrient status, due to increased nutrient use, aging of the aging process, immune system weakness, but also insomnia.
A very important component in MELATONINE COMPLEX * is Melatonin, a hormone that has been scientifically proven to contribute to the synchronization of our biological clock and thus a good sleep quality in sleeplessness due to physical or psychological factors. As a precursor of Melatonin, Tryptophan enhances the action of melatonin.
The same can be said of passion flower and Valerian who have been known for decades.
Take 1 capsule in the evening before bedtime.
Do not exceed the recommended daily dose. Keep out of the reach of young children.
Nutritional supplements should not be used as a replacement for a varied, balanced diet and healthy lifestyle.
Children, pregnant women and breast-feeding women should consult your pharmacist.
Inform with concurrent ingestion of medicines.
No prolonged use without expert advice.
Range of usage
- Disadvantage due to time difference
- Irregular day-night rhythm
- Stress situations
CompositionIngredients per capsule
Passiflora incarnata L. (Passion Flower) Dry Extract 200mg, Valeriana Officinalis L. (True Valerian) Dry Extract 200mg, L-Tryptophan 200mg, Gelatin, Anticlotants (Magnesium Silicate, Magnesium Stearate, Silicon Dioxide), Melatonin 295mcg
ReferencesMartin JL, et al. (2007). Sleep disorders. In RJ Ham et al., eds., Primary Care Geriatrics: A Case-Based Approach, 5th ed., pp. 391-400. St. Louis: Mosby Elsevier.
Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev 2002;(2):CD001520.
Melatonin and its relevance to jet lag. Brown GM, Pandi-Perumal SR, et al. Travel Med Infect Dis. 2009 Mar;7(2):69-81. Review.
Brzezinski A, Vangel MG, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005 Feb;9(1):41-50.
Buscemi N, Vandermeer B, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005 Dec;20(12):1151-8.
Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. Garzón C, Guerrero JM, et al. Aging Clin Exp Res. 2009 Feb;21(1):38-42.
Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. Wilhelmsen M, Amirian I, Reiter RJ, Rosenberg J, Gögenur I. J Pineal Res. 2011 Apr 18.
Brown, E., Hurd, N. S., McCall, S., and Ceremuga, T. E. Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. AANA.J 2007;75(5):333-337.
Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7
Elsas SM, D. J. Rossi DJ, Rabera J, White G, et al.Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. Phytomedicine. 2010 October ; 17(12): 940–949
Dhawan K, Dhawan S, Chhabra S. Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: A non -habit forming anxiolytic. J Pharm Pharmaceut Sci2003;6(2):215–22
Giedke, H. and Breyer-Pfaff, U. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry 2000;33(6):239
Ziegler G, Ploch M, Miettinen-Baumann A, Collet W. | Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study. | Eur J Med Res. | 2002 Nov 25;7(11):480-6.
Slominski, Andrzej; Semak, Igor; Pisarchik, Alexander; Sweatman, Trevor; Szczesniewski, Andre; Wortsman, Jacobo. "Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells". FEBS Letters. 511 (1-3): 102–106.
Schaechter JD, Wurtman RJ (Nov 1990). "Serotonin release varies with brain tryptophan levels" (PDF). Brain Research. 532 (1-2): 203–10. doi:10.1016/0006-8993(90)91761-5.
Wurtman RJ, Anton-Tay F (1969). "The mammalian pineal as a neuroendocrine transducer" (PDF). Recent Progress in Hormone Research. 25: 493–522. doi:10.1016/b978-0-12-571125-8.50014-4.
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