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Supplies Vitamin D to the body in a safe manner.
Prijs : € 120 parels VITAMINE D COMPLEX FORTE

  at your pharmacist

The term Vitamin D is a group of fat-soluble prohormones, of which the two major forms are Vitamin D2 (ergocalciferol, the plant form) and Vitamin D3 (cholecalciferol, the animal form).  Vitamin D3 can be produced by the skin when exposed to ultraviolet light from the sun, which in the traditional interpretation of the term "Vitamin" could be understood as Vitamin D not actually being a real Vitamin. However, in most cases the synthesis via the skin in western Europe remains inadequate and humans are dependent on supply from external sources, that's the reason why this substance is generally still regarded as a vitamin.  Today, Vitamin D3 is often regarded as a prohormone, because it is converted into the active form (calcitriol) by hydroxylation in the liver and kidneys. Vitamin D2 has to be metabolised in the body to Vitamin D3 and then to be converted to the active form (calcitriol).
Our current western diet does not contain enough Vitamin D, since very few foods (egg yolks, mushrooms, cod-liver oil) have a readily absorbable form of Vitamin D. Research shows that in Western Europe, the Vitamin D intake at 3.2 µg/d from food in almost three quarters of adults is too low, while the recommended daily amount (RDA-value) of Vitamin D is 5 µg.
It is therefore not surprising that meta-analyses performed in laboratories in western Europe demonstrate that three quarters of the population over 45 years old show a shortage of Vitamin D (<30ng/ml).

Vitamin D plays an important role in various physiological processes in the body:
• Vitamin D regulates the levels of calcium and phosphate in the blood through stimulating its absorption from food in the intestines and also through stimulating the reuptake of calcium and phosphate in the kidneys. It reduces the mobilization of calcium from the bones (by lowering parathormone). These processes mean sufficient vitamin D in the body is essential for normal bone and tooth mineralisation.
• Sufficient Vitamin D is also essential for the optimal functioning of the immune system, through its influence on immunosuppression, phagocytosis and anti-tumour activity.
• Sufficient Vitamin D contributes to the maintenance of normal muscle functions.
• Vitamin D also plays a role in our cell division.


Instructions for use
1 pearl per day during meal.

VITAMINE D COMPLEX FORTE of Natural Energy contains 120 pearls each 25 µg (= 1000 IU) Vitamin D3 (Cholecalciferol) under a raft absorbable form, for a perfect bio-availability.

Children from age 6
The recommended dose for children with a Vitamin D deficiency is 1 Pearl per 10 kg of body weight per day to start. As a maintenance dose we recommend 1 Pearl per 20 kg of body weight per day.

For children from 6 years a pack VITAMINE D COMPLEX JUNIOR of Natural Energy contains 240 pearls that each 6, 5 g (= 260 IU) Vitamin D3 (cholecalciferol) under a raft absorbable form, for a perfect bio-availability.

Do not exceed the recommended daily dose.
Keep out of reach of young children.
Nutritional supplements should not replace a varied and balanced diet and a healthy lifestyle.

Not allowed for children under 11.
Pregnant women and women who are breastfeeding, consult your pharmacist before use.
Check with simultaneous intake of medicines.
No long-term use without professional advice.

NUT 1429/30
NUT 1429/19


Range of usage

• For a normal calcium content in our body
• Helps maintain normal bone and tooth tissue
• Plays a role in cell division
• Maintains the normal muscle function
• For the healthy functioning of the immune system.

Ingredients per Pearl
Virgin olive oil, Gelatin, Gelling agent (Glycerol), Water, Vitamin D3 (Cholecalciferol) 25μg (500% RI

 RI: Reference intake
Vitamin D: The Merck Manual of Diagnosis and Therapy. Laatste volledige review/revisie april 2007 door Larry E. Johnson, MD, PhD

Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. (2004) Am J Clin Nutr 80:1678S-1688S.

Rajakumar K. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. (2003) Pediatrics 112:e132-e135.

Huldschinsky, K. Heilung von Rachitis durch Künstliche Höhensonne Deutsche med. Wochenschrift, 1919,45, 712–713

Hess AF, Unger LJ, Pappenheimer AM. Experimental rickets in rats. III. The prevention of rickets in rats by exposure to sunlight. 1922. J. Biol. Chem. 50, 77-81. (2002) J Biol Chem 277:e1-e2.

McCollum EV, Simmonds N, Becker JE, et al. Studies on experimental rickets. XXI. An experimental demonstration of the existence of a vitamin which promotes calcium deposition (1922) J Biol Chem 53:293-312.

Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. (2006) Am J Clin Nutr 84:694-697.
Armas LA, Hollis BW, Heaney RP. (2004) J Clin Endocrinol Metab 89:5387-5391.

Coates ME. Requirements of different species for vitamins. (1968) Proc Nutr Soc 27:143-148.

Trivedi DP, Doll R, Khaw KT. (2003) BMJ 326:469.Uit dit onderzoek blijkt dat oudere patiënten 22% minder botbreuken hebben (in vergelijking met de placebogroep) als ze vijf jaar lang om de vier maanden orale dosis van 100.000 IE vitamine D krijgen. Dit komt overeen met een dagdosis van iets meer dan 800 IE. Als werd gekeken naar typische osteoporosebreuken in heup, pols, onderarm en rugwervels was de kans op fracturen in de Vitamine D-groep met 33% verlaagd.
Hoogendijk WJ, Lips P, Dik MG, et al. Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. (2008) Arch Gen Psychiatry 65:508-512.

Neonatal Vitamin D Status and Risk of Schizophrenia, Archives of General Psychiatry, vol 67 no 9, September 2010
Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. (1999) Am J Clin Nutr 69:842-856.

De laagste dosering die in deze compilatie van onderzoeken naar de toxiciteit van vitamine D gepaard ging met toxiciteit betrof een inneming van 250 µg (10.000 IU) vitamine D per dag gedurende 390 dagen, waarbij een 25(OH)D-spiegel werd gemeten van 608 nmol/l.
Norman AW. Sunlight, season, skin pigmentation, vitamin D, and 25-hydroxyvitamin D: integral components of the vitamin D endocrine system. (1998) Am J Clin Nutr 67:1108-1110.

MacLaughlin JA, Anderson RR, Holick MF. Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. (1982) Science 216:1001-1003.

Tangpricha V, Turner A, Spina C, et al. Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density. (2004) Am J Clin Nutr 80:1645-1649.

Levis S, Gomez A, Jimenez C, et al. Vitamin d deficiency and seasonal variation in an adult South Florida population. (2005) J Clin Endocrinol Metab 90:1557-1562.

Sayre, Robert M., John C. Dowdy (2007). Darkness at Noon: Sunscreens and Vitamin D3. Photochemistry and Photobiology 83 (2): 459. DOI:10.1562/2006-06-29-RC-956.

Holick MF. High prevalence of vitamin D inadequacy and implications for health. (2006) Mayo Clin Proc 81:353-373.
Muskiet F.A.J., van der Veer E.. Vitamine D: waar liggen de grenzen van deficiëntie, adequate status en toxiciteit? (2007) Ned Tijdschr Klin Chem Labgeneesk 32:150-158

Vieth R, Bischoff-Ferrari H, Boucher BJ, et al. The urgent need to recommend an intake of vitamin D that is effective. (2007) Am J Clin Nutr 85:649-650.

European Commission; Health & Consumer Protection Directorate-General. 2002. Opinion of the Scientific Committee on Food on the tolerable upper intake level of vitamin D' (expressed on 4 December 2002). European Commission; Health & Consumer Protection Directorate-General , Bruxelles/Brussel - Belgium.
Hill TR, O'brien MM, Cashman KD, et al. Vitamin D intakes in 18-64-y-old Irish adults. (2004) Eur J Clin Nutr 58:1509-1517.
Gezondheidsraad - Voedingsnormen: calcium, vitamine D, thiamine, riboflavine, niacine, pantotheenzuur en biotine. Den Haag: Gezondheidsraad, 2000; publicatienr 2000/12. ISBN 905549-​323-​6

Gezondheidsraad - Naar een toereikende inname van vitamine D. Gezondheidsraad, 2008; publicatienr. 2008/15. ISBN 978​90-​5549-​729-​4. In dit rapport wordt extra vitamine D geadviseerd aan de volgende groepen: kinderen beneden 4 jaar, personen met een donkere huidkleur, vrouwen die zwanger zijn of borstvoeding geven, vrouwen die een sluier dragen, vrouwen boven de 50 en mannen boven de 70. De Gezondheidsraad adviseert in dit rapport om de voorlichting over het belang van extra vitamine D uit voedingssupplementen te verbeteren en concudeert dat de door de Gezondheidsraad opgestelde voedingsnormen voor vitamine D uit 2000 aan herziening toe zijn.
Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. (1999) Am J Clin Nutr 69:842-856..
Vieth R, Bischoff-Ferrari H, Boucher BJ, et al. The urgent need to recommend an intake of vitamin D that is effective. (2007) Am J Clin Nutr 85:649-650.. In dit editorial in het American Journal of Clinical Nutrition uiten vooraanstaande vitamine D-onderzoekers hun frustratie dat de uitkomsten van wetenschappelijk onderzoek op het gebied van vitamine D zich nog steeds niet hebben vertaald in hogere aanbevelingen.
Professor Gertjan Schaafsma: ‘Adviezen voor vitamine D te laag’ . Vitamine Informatie Bureau Nieuwsbrief Jaargang 1, nr. 1, najaar 2007. Prof. Schaafsma is lector aan de Hogeschool Arnhem Nijmegen en voormalig hoogleraar Voeding aan de Universiteit van Wageningen. Gertjan Schaafsma is daarnaast onder meer lid van de Gezondheidsraad, de Nederlandse Academie van Voedingswetenschappen en de wetenschappelijke raad van de Nationale Osteoporose Stichting.
Heaney RP. The Vitamin D requirement in health and disease. (2005) J Steroid Biochem Mol Biol 97:13-19.
Voedingscentrum - Nieuw vitamine D-advies. 30 september 2008

Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. (2005) Altern Med Rev 10:94-111.
Visser M, Deeg DJ, Puts MT, et al. Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. (2006) Am J Clin Nutr 84:616-22; quiz 671-2.
Binkley N, Krueger D, Cowgill CS, et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. (2004) J Clin Endocrinol Metab 89:3152-3157.
Wielders JP, van Dormaël PD, Eskes PF, et al. Ernstige vitamine D-deficiëntie bij ruim de helft van de niet-westerse allochtone zwangeren en hun pasgeborenen (2006) Ned Tijdschr Geneeskd 150:495-499.

Grootjans-Geerts I. Vitamine D: belangrijk al vóór de wieg en tot het graf. (2006) Ned Tijdschr Geneeskd 150:470-472.

Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. (2007) Am J Clin Nutr 85:860-868.

Holick MF. The vitamin D epidemic and its health consequences. (2005) J Nutr 135:2739S-2748S.

Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. (2007) Am J Clin Nutr 85:860-868.

Holvik K, Meyer HE, Haug E, et al. 2005) Eur J Clin Nutr 59:57-63. Deze studie toont aan dat een significant percentage (ongeveer een derde) van verschillende immigrantengroepen in Noorwegen vitamine D-deficiënt zijn (serumwaarden calcidiol minder dan 25 nmol/l).
Uitterlinden AG, Ralston SH, Brandi ML, et al. The association between common vitamin-D-receptor gene variations and osteoporosis: a participant-level meta-analysis. (2006) Ann Intern Med 145:255-264.

Melamed ML, Muntner P, Michos ED, et al. Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004. (2008) Arterioscler Thromb Vasc Biol 28:1179-1185.

Venning G. Recent developments in vitamin D deficiency and muscle weakness among elderly people. (2005) BMJ 330:524-526.. In dit artikel in de British Medical Journal wordt gepleit voor vitamine D-suppletie met minimaal 800 IE (20 µg) ter preventie van fracturen en vallen bij aan huis gebonden ouderen.

Lips P, Graafmans WC, Ooms ME, et al. Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. (1996) Ann Intern Med 124:400-406.. In deze studie werd geen effect gevonden van het dagelijks toedienen van 400 IE vitamine D3 gedurende (maximaal) 4 jaar op het heupfractuurrisico bij bejaarden van gemiddeld 80 jaar.
Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of Vitamin D on falls: a meta-analysis. (2004) JAMA 291:1999-2006.. In deze overtuigende meta-analyse bleek dat toediening van extra vitamine D het relatieve risico van een val met 30% vermindert. De resultaten met een dagdosis van 800 IE waren het meest overtuigend.
Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. (2005) JAMA 293:2257-2264.

Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. (2006) Am J Clin Nutr 84:18-28.
Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. (2004) Am J Med 116:634-639.

Brown SJ. The role of vitamin D in multiple sclerosis. (2006) Ann Pharmacother 40:1158-1161.

Lack of vitamin D may increase heart disease risk American Heart Association rapid access journal report 01/07/2008
Scragg R, Jackson R, Holdaway IM, Lim T, Beaglehole R. (1990). Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study.. Int J Epidemiol.19 (3): 559-563.

Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. (2007) Arch Intern Med 167:1730-1737.

Lehmann B. The vitamin D3 pathway in human skin and its role for regulation of biological processes. (2005) Photochem Photobiol 81:1246-1251.

V. Fedirko et. al. Effect of vitamin D and calcium supplementation on markers of apoptosis in normal colon mucosa: Results from a randomized clinical trial, American Association for Cancer Research Annual Meeting 13 April 2008, Abstract 464.

A. Thomas, C. Dash, R.M. Bostick, Associations of calcium and vitamin D with E-cadherin and β-catenin expression in normal-appearing rectal tissue; markers of adenomatous polyps II (MAP II) case-control study, American Association for Cancer Research Annual Meeting, 13 April 2008, Abstract 565.
B.-Y. Bao et al., Protective role of 1a, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells, The International Journal of Cancer, Volume 122, Issue 12, 15 June 2008, Pages: 2699-2706

Hyppönen E, Läärä E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. (2001) Lancet 358:1500-1503..

Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. (2008) Circulation 117:503-511.

Hsia J, Heiss G, Ren H, et al. Calcium/vitamin D supplementation and cardiovascular events. (2007) Circulation 115:846-854.

Michos ED, Blumenthal RS. Vitamin D supplementation and cardiovascular disease risk. (2007) Circulation 115:827-828.
Hathcock JN, Shao A, Vieth R, et al. Risk assessment for vitamin D. (2007) Am J Clin Nutr 85:6-18.

Burns J, Paterson CR. Single dose vitamin D treatment for osteomalacia in the elderly. (1985) Br Med J (Clin Res Ed) 290:281-282.

Diamond TH, Ho KW, Rohl PG, et al. Annual intramuscular injection of a megadose of cholecalciferol for treatment of vitamin D deficiency: efficacy and safety data. (2005) Med J Aust 183:10-12
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